Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-<i>b</i>]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents
Abdulrhman Alsayari,
Abdullatif Bin Muhsinah,
Yahya I. Asiri,
Faiz A. Al-aizari,
Nabila A. Kheder,
Zainab M. Almarhoon,
Hazem A. Ghabbour,
Yahia N. Mabkhot
Affiliations
Abdulrhman Alsayari
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia
Abdullatif Bin Muhsinah
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia
Yahya I. Asiri
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia
Faiz A. Al-aizari
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Nabila A. Kheder
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Zainab M. Almarhoon
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Hazem A. Ghabbour
Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
Yahia N. Mabkhot
Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia
The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, 1H and 13C NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.
