Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications
Nan Yang,
Changyu Cao,
Xinyi Lv,
Tian Zhang,
Jinjun Shao,
Xuejiao Song,
Wenjun Wang,
Peng Chen,
Wei Huang,
Xiaochen Dong
Affiliations
Nan Yang
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Changyu Cao
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Xinyi Lv
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Tian Zhang
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Jinjun Shao
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Xuejiao Song
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Wenjun Wang
School of Physical Science and Information Technology Liaocheng University Liaocheng China
Peng Chen
School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore
Wei Huang
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Xiaochen Dong
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing China
Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high tumor specificity by responding to TME (overexpressed hydrogen peroxide (H2O2) and glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated CDT can further enhance the catalytic activity and controllability of the treatment. In addition, other photo‐induced therapies, including photodynamic and photothermal therapy (PDT, PTT), may synergize with CDT to obtain boosting treatment efficacy and avoid multidrug resistance. In this minireview, we summarize the recent advances in photo‐assisted CDT, including PTT‐facilitated CDT and PDT‐facilitated CDT. More importantly, the challenges encountered in the treatment process are discussed and potential development directions are suggested to facilitate the clinical translation of photo‐assisted CDT in the future.
