MedComm (Aug 2024)
Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop‐CN model (NCRCID‐CHESS 2106): a prospective multicenter study
- Xiaoyan Li,
- Shanghao Liu,
- Ying Guo,
- Hongmei Zu,
- Huiling Xiang,
- Shaoqi Yang,
- Xiaoning Zhang,
- Fanping Meng,
- Yangzhen Bianba,
- Jie Li,
- Fei Liu,
- Chuang Lei,
- Jiaojian Lv,
- Qiao‐hua Yang,
- Wei Fu,
- Wei Ye,
- Jiafang Chen,
- Yanjing Gao,
- Caiyun Wu,
- Ningning Wang,
- Qi Zheng,
- Fang Wang,
- Jiali Yu,
- Jing Wang,
- Xiaoting Yang,
- Xiangmei Wang,
- Yayuan Liu,
- Xuelan Zhao,
- Chenxi Wu,
- Wei Gou,
- Jasmohan S. Bajaj,
- Fu‐Sheng Wang,
- Junliang Fu,
- Xiaolong Qi
Affiliations
- Xiaoyan Li
- Medical School of Chinese PLA Beijing China
- Shanghao Liu
- Center of Portal Hypertension Department of Radiology Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- Ying Guo
- Department of Hepatology The Third People's Hospital of Taiyuan Taiyuan China
- Hongmei Zu
- Department of Gastroenterology The Fourth People's Hospital of Qinghai Province Xining China
- Huiling Xiang
- Department of Gastroenterology and Hepatology Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease Tianjin China
- Shaoqi Yang
- Department of Gastroenterology The General Hospital of Ningxia Medical University Yinchuan China
- Xiaoning Zhang
- Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases Beijing China
- Fanping Meng
- Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases Beijing China
- Yangzhen Bianba
- Department of Hepatology The Third People's Hospital of Tibet Autonomous Region Lhasa China
- Jie Li
- Department of Infectious Diseases Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School Nanjing University Nanjing China
- Fei Liu
- Department of Infectious Diseases Hunan Key Laboratory of Viral Hepatitis Xiangya Hospital Central South University Changsha China
- Chuang Lei
- Department of Infectious Diseases The First People's Hospital of Changde City Changde China
- Jiaojian Lv
- Department of Infectious Disease Lishui City People's Hospital Lishui China
- Qiao‐hua Yang
- Hepatology Department of Infectious Diseases Center The First People's Hospital of Huaihua Huaihua China
- Wei Fu
- Department of Hepatology Shenyang 739 Hospital Shenyang China
- Wei Ye
- Liver Cirrhosis Treatment Center Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine Nanjing China
- Jiafang Chen
- Department of Gastroenterology Datong City Fourth People's Hospital Datong China
- Yanjing Gao
- Department of Gastroenterology Qilu Hospital of Shandong University Jinan China
- Caiyun Wu
- Department of Hepatology Third People′s Hospital of Linfen City Linfen China
- Ningning Wang
- Department of Gastroenterology The First Hospital of China Medical University Shenyang China
- Qi Zheng
- Department of Hepatology Hepatology Research Institute The First Affiliated Hospital Fujian Medical University Fuzhou China
- Fang Wang
- Department of Hepatology Shenzhen Third People's Hospital, National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology Shenzhen China
- Jiali Yu
- Department of Gastroenterology The First Affiliated Hospital of Dalian Medical University Dalian China
- Jing Wang
- Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical College Baotou China
- Xiaoting Yang
- Department of Gastroenterology Wuzhong People's Hospital Wuzhong China
- Xiangmei Wang
- Department of Severe Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou China
- Yayuan Liu
- Department of Gastroenterology Central hospital of Dandong Dandong China
- Xuelan Zhao
- Department of Gastroenterology Liver Diseases Chongqing Public Health Medical Center Chongqing China
- Chenxi Wu
- Liver Disease Diagnosis and Treatment Center Yiyang Fourth People's Hospital Yiyang China
- Wei Gou
- Qingdao Sixth People's Hospital Qingdao China
- Jasmohan S. Bajaj
- Division of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University and Central Virginia Veterans Healthcare System Richmond Virginia USA
- Fu‐Sheng Wang
- Medical School of Chinese PLA Beijing China
- Junliang Fu
- Medical School of Chinese PLA Beijing China
- Xiaolong Qi
- Center of Portal Hypertension Department of Radiology Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- DOI
- https://doi.org/10.1002/mco2.627
- Journal volume & issue
-
Vol. 5,
no. 8
pp. n/a – n/a
Abstract
Abstract Minimal hepatic encephalopathy (MHE) has a substantial impact on the clinical outcomes and quality of life (QOL) of patients with cirrhosis. However, timely diagnosis and intervention are challenging due to sophisticated diagnostic methods. In this study, 673 healthy controls and 905 patients with cirrhosis were screened, and 660 healthy controls and 757 patients with cirrhosis, divided into the test (292 patients) and validation (465 patients) cohort, were analyzed after screening. A diagnostic model of the Stroop test (Stroop‐CN) was constructed by multivariate linear regression based on the results of healthy controls. The prevalence of MHE and the comparison results with psychometric hepatic encephalopathy score through the Stroop‐CN model were stable in the test and validation cohorts. Moreover, the prevalence of MHE remained significantly higher in patients with worse disease conditions marked as high Child–Pugh grades and the Model for End‐stage Liver Disease and Sodium (MELD‐Na) scores in the test and validation cohort. The EuroQol 5‐D questionnaire revealed that patients with MHE had a worse QOL than those without MHE both in the test and validation cohort. In conclusion, an easy and practical Stroop‐CN model for MHE diagnosis based on the EncephalApp is established. It is found that a considerable number of Chinese patients with cirrhosis experience MHE, which significantly impacts their QOL.
Keywords
