BONE DENSITOMETRY INDICATORS IN POSTMENOPAUSAL WOMEN DEPENDING ON TNFSF11 GENE RS9594738 (C>T) POLYMORPHISM

Abstract

Indexes of bone tissue mineral density of various sites of skeleton at 483 postmenopausal women depending on genotype of TNFSF11 gene rs9594738 (C>T) polymorphism were studied. It was established that women, who had CT and a TT genotypes in comparison with CC genotype owners were characterized by significantly lowered (Р<0,001 – P=0,026) densitometry indexes in zone of L1-L4 lumbar vertebrae, left and right proximal femoral departments, including left and right femoral necks, and also forearm bones distal department. Results of this research can be used for development of detection criteria of predisposition to postmenopausal osteoporosis onset and for increase of treatment-and-prophylactic actions effectiveness.

Keywords

• tnfsf11 gene
• rs9594738
• women
• postmenopause
• osteoporosis