Nature Communications (Feb 2017)
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
- Lu Zhu,
- Joana Almaça,
- Prasanna K. Dadi,
- Hao Hong,
- Wataru Sakamoto,
- Mario Rossi,
- Regina J. Lee,
- Nicholas C. Vierra,
- Huiyan Lu,
- Yinghong Cui,
- Sara M. McMillin,
- Nicole A. Perry,
- Vsevolod V. Gurevich,
- Amy Lee,
- Bryan Kuo,
- Richard D. Leapman,
- Franz M. Matschinsky,
- Nicolai M. Doliba,
- Nikhil M. Urs,
- Marc G. Caron,
- David A. Jacobson,
- Alejandro Caicedo,
- Jürgen Wess
Affiliations
- Lu Zhu
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Joana Almaça
- Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, University of Miami Miller School of Medicine
- Prasanna K. Dadi
- Department of Molecular Physiology and Biophysics, Vanderbilt University
- Hao Hong
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Wataru Sakamoto
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Mario Rossi
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Regina J. Lee
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Nicholas C. Vierra
- Department of Molecular Physiology and Biophysics, Vanderbilt University
- Huiyan Lu
- Mouse Transgenic Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases
- Yinghong Cui
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Sara M. McMillin
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- Nicole A. Perry
- Department of Pharmacology, Vanderbilt University
- Vsevolod V. Gurevich
- Department of Pharmacology, Vanderbilt University
- Amy Lee
- Department of Molecular Physiology and Biophysics, University of Iowa
- Bryan Kuo
- Laboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering
- Richard D. Leapman
- Laboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering
- Franz M. Matschinsky
- Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
- Nicolai M. Doliba
- Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
- Nikhil M. Urs
- Department of Cell Biology, Duke University Medical Center
- Marc G. Caron
- Department of Cell Biology, Duke University Medical Center
- David A. Jacobson
- Department of Molecular Physiology and Biophysics, Vanderbilt University
- Alejandro Caicedo
- Division of Endocrinology, Department of Medicine, Diabetes and Metabolism, University of Miami Miller School of Medicine
- Jürgen Wess
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
- DOI
- https://doi.org/10.1038/ncomms14295
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta cells.
