PLoS ONE (Jan 2013)

Prevalence of dementia and subtypes in Valladolid, northwestern Spain: the DEMINVALL study.

  • Miguel Angel Tola-Arribas,
  • María Isabel Yugueros,
  • María José Garea,
  • Fernando Ortega-Valín,
  • Ana Cerón-Fernández,
  • Beatriz Fernández-Malvido,
  • Antonio San José-Gallegos,
  • Marta González-Touya,
  • Ana Botrán-Velicia,
  • Vanessa Iglesias-Rodríguez,
  • Bárbara Díaz-Gómez

DOI
https://doi.org/10.1371/journal.pone.0077688
Journal volume & issue
Vol. 8, no. 10
p. e77688

Abstract

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OBJECTIVE:To describe the prevalence of dementia and subtypes in a general elderly population in northwestern Spain and to analyze the influence of socio-demographic factors. METHODS:Cross-sectional, two-phase, door-to-door, population-based study. A total of 870 individuals from a rural region and 2,119 individuals from an urban region of Valladolid, Spain, were involved. The seven-minute screen neurocognitive battery was used in the screening phase. A control group was included. RESULTS:A total of 2,170 individuals aged 65 to 104 years (57% women) were assessed. There were 184 subjects diagnosed with dementia. The crude prevalence was 8.5% (95% CI: 7.3-9.7). Age- and sex-adjusted prevalence was 5.5 (95% CI: 4.5-6.5). Main subtypes of dementia were: Alzheimer's disease (AD) 77.7%, Lewy Body disease, 7.6% and vascular dementia (VD) 5.9%. Crude prevalences were 6.6% (AD), 0.6% (Lewy Body disease), and 0.5% (VD). Dementia was associated with age (OR 1.14 for 1-year increase in age), female sex (OR 1.79) and the absence of formal education (OR 2.53 compared to subjects with primary education or more). CONCLUSION:The prevalence of dementia in the study population was lower than the most recent estimates for Western Europe. There was a high proportion of AD among all dementia cases and very low prevalence of VD. Old age, female sex, and low education level were independent risk factors for dementia and AD.