Scientific Reports (Feb 2021)

Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy

  • Yoei Miyabe,
  • Kazunori Karasawa,
  • Kenichi Akiyama,
  • Shota Ogura,
  • Tomo Takabe,
  • Naoko Sugiura,
  • Momoko Seki,
  • Yuko Iwabuchi,
  • Norio Hanafusa,
  • Keiko Uchida,
  • Kosaku Nitta,
  • Takahito Moriyama

DOI
https://doi.org/10.1038/s41598-021-82967-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Abstract The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0–1, II: 2–4, and III: 5–7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer with increasing O-grades, and the renal survival rate by the Kaplan–Meier method was 94.1%, 86.9%, and 74.1% for O-grades I, II, and III, respectively. The hazard ratios (HRs) for O-grades II and III with reference to O-grade I were 2.8 (95% confidence interval [CI] 1.3–6.0) and 6.3 (95% CI 2.7–14.5), respectively. In the multivariate analysis, mean arterial pressure and eGFR, proteinuria at the time of biopsy, treatment of corticosteroids/immunosuppressors, and O-grade (HR 1.63; 95% CI 1.11–2.38) were the independent factors predicting renal prognosis. Among the nine groups classified using the O-grade and Japanese clinical-grade, the renal prognosis had an HR of 15.2 (95% CI 3.5–67) in the severest group. The O-grade classified by the total score of the Oxford classification was associated with renal prognosis.