Comparison study between commercial and modified grains mix WHO formula F-100 to weight, serum amylase and lipase in children aged 1-3 years

Abstract

BACKGROUND: Children with cow´s milk allergy require special formulas contain ingredients that doesn´t cause allergies or intolerances. Ready-to-use modified grains mix formula at Dr. Soetomo hospital based on modified gain mix WHO formula F-100, while commercial grain mix products fortified with micronutrients and amylase enzyme can be used as alternative if it is not available in the hospital. This study aims to compare the differences of weight gain, amylase and lipase enzyme levels between commercial (CGMF) and modified grain mix WHO formula F-100 (CGMF) in children aged 1-3 years. METHODS: the study were quasi-experimental trials randomized controlled design, subjects were children aged 1-3 years who drink soy formula with cow´s milk allergy at outpatient clinic Dr. Soetomo hospital divided into commercial grain mix (CGMF) and modified grain mix WHO formula F-100 (MGMFW) groups. The evaluation of weight gain, levels of serum amylase and lipase were done before and after of formula consumption. Statistical analysis incuding Chi-square Test, Independent sample T-Test, Paired sample T-Test, and Anacova using SPSS ver. 17.0 (IBM, US). RESULTS: a total of 17 subjects in CGMF and 16 subjects in MGMFW groups. There are significant difference in body weight gain, serum amylase and lipase level before and after the administration of CGMF and MGMFW (p=0.05), but the difference between both treatment groups were not significant (p=0,005). CONCLUSION: commercial formula is equivalent to modified grains mix in weight gain, serum amylase and lipase levels so that it can be used as an alternative formula in the nutritional management of cow´s milk allergy in children aged 1-3 years old to ensure optimal growth.

Keywords

• grain mix formula
• cow´s milk allergy
• weight gain
• amylase
• lipase.