Generation of an iPSC line (ZZUNEUi016-A) derived from a hypertrophic cardiomyopathy patient with the heterozygote mutation in MYH7 gene

Guangli Guo; Wanrong Fu; Xiaowei Li; Jianzeng Dong; Xiaoyan Zhao; Yanzhou Zhang

Stem Cell Research (May 2021)

Generation of an iPSC line (ZZUNEUi016-A) derived from a hypertrophic cardiomyopathy patient with the heterozygote mutation in MYH7 gene

Guangli Guo,
Wanrong Fu,
Xiaowei Li,
Jianzeng Dong,
Xiaoyan Zhao,
Yanzhou Zhang

Affiliations

Guangli Guo: Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People’s Republic of China
Wanrong Fu: Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People’s Republic of China
Xiaowei Li: Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People’s Republic of China
Jianzeng Dong: Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People’s Republic of China; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, People’s Republic of China
Xiaoyan Zhao: Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People’s Republic of China; Corresponding authors.
Yanzhou Zhang: Department of Cardiology, Centre for Cardovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, People’s Republic of China; Corresponding authors.

Journal volume & issue: Vol. 53
p. 102262

Abstract

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HCM is one of the most common inheritable cardiac disease. In our study, we established a human-induced pluripotent stem cells (hiPSCs) line (ZZUNEUi016-A) from a hypertrophic cardiomyopathy patient with the pathogenic heterozygote mutation in MYH7 gene. ZZUNEUi016-A expressed pluripotency markers with normal karyotype and showed the ability to differentiate into all three germ layers in vitro.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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