Chemotaxing neutrophils enter alternate branches at capillary bifurcations

Xiao Wang; Mokarram Hossain; Ania Bogoslowski; Paul Kubes; Daniel Irimia

doi:10.1038/s41467-020-15476-6

Nature Communications (May 2020)

Chemotaxing neutrophils enter alternate branches at capillary bifurcations

Xiao Wang,
Mokarram Hossain,
Ania Bogoslowski,
Paul Kubes,
Daniel Irimia

Affiliations

Xiao Wang: BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Shriners Burns Hospital
Mokarram Hossain: Department of Physiology and Biophysics, University of Calgary
Ania Bogoslowski: Department of Physiology and Biophysics, University of Calgary
Paul Kubes: Department of Physiology and Biophysics, University of Calgary
Daniel Irimia: BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Shriners Burns Hospital

DOI: https://doi.org/10.1038/s41467-020-15476-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Neutrophils mobilize rapidly and travel through the vasculature and microcirculation en masse in response to inflammatory stimuli. Here the authors use a microfluidic device and intravital microscopy to show neutrophils move through tissues in a highly ordered pattern, taking turns to file into alternate branches at bifurcations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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