Nature Communications (May 2018)
Elucidating the genetic architecture of reproductive ageing in the Japanese population
- Momoko Horikoshi,
- Felix R. Day,
- Masato Akiyama,
- Makoto Hirata,
- Yoichiro Kamatani,
- Koichi Matsuda,
- Kazuyoshi Ishigaki,
- Masahiro Kanai,
- Hollis Wright,
- Carlos A. Toro,
- Sergio R. Ojeda,
- Alejandro Lomniczi,
- Michiaki Kubo,
- Ken K. Ong,
- John. R. B. Perry
Affiliations
- Momoko Horikoshi
- Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences
- Felix R. Day
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- Masato Akiyama
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Makoto Hirata
- Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Koichi Matsuda
- Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Kazuyoshi Ishigaki
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Masahiro Kanai
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Hollis Wright
- Primate Genetics Section/Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University
- Carlos A. Toro
- Primate Genetics Section/Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University
- Sergio R. Ojeda
- Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University
- Alejandro Lomniczi
- Primate Genetics Section/Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Ken K. Ong
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- John. R. B. Perry
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- DOI
- https://doi.org/10.1038/s41467-018-04398-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
The timing of female reproductive capacity is influenced by genetic and environmental factors. Here, in genome-wide association studies, the authors identify genetic loci for age at menarche and onset of menopause in Japanese women, and highlight differences with European populations.
