FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan; Jingjing Liang; Ju Gao; Luwen Wang; Hisashi Fujioka; The Alzheimer Disease Neuroimaging Initiative; Xiaofeng Zhu; Xinglong Wang

doi:10.1038/s41467-019-13962-0

Nature Communications (Jan 2020)

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan,
Jingjing Liang,
Ju Gao,
Luwen Wang,
Hisashi Fujioka,
The Alzheimer Disease Neuroimaging Initiative,
Xiaofeng Zhu,
Xinglong Wang

Affiliations

Tingxiang Yan: Department of Pathology, Case Western Reserve University
Jingjing Liang: Department of Population and Quantitative Health Sciences, Case Western Reserve University
Ju Gao: Department of Pathology, Case Western Reserve University
Luwen Wang: Department of Pathology, Case Western Reserve University
Hisashi Fujioka: Electron Microscopy Core Facility, Case Western Reserve University
The Alzheimer Disease Neuroimaging Initiative
Xiaofeng Zhu: Department of Population and Quantitative Health Sciences, Case Western Reserve University
Xinglong Wang: Department of Pathology, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-019-13962-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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