mBio (Feb 2021)
Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant <i>Enterobacterales</i> in the United States
- Victor I. Band,
- Sarah W. Satola,
- Richard D. Smith,
- David A. Hufnagel,
- Chris Bower,
- Andrew B. Conley,
- Lavanya Rishishwar,
- Suzanne E. Dale,
- Dwight J. Hardy,
- Roberto L. Vargas,
- Ghinwa Dumyati,
- Marion A. Kainer,
- Erin C. Phipps,
- Rebecca Pierce,
- Lucy E. Wilson,
- Matthew Sorensen,
- Erik Nilsson,
- I. King Jordan,
- Eileen M. Burd,
- Monica M. Farley,
- Jesse T. Jacob,
- Robert K. Ernst,
- David S. Weiss
Affiliations
- Victor I. Band
- Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA
- Sarah W. Satola
- Emory Antibiotic Resistance Center, Atlanta, Georgia, USA
- Richard D. Smith
- Department of Microbial Pathogenesis, University of Maryland—Baltimore, Baltimore, Maryland, USA
- David A. Hufnagel
- Emory Vaccine Center, Atlanta, Georgia, USA
- Chris Bower
- Georgia Emerging Infections Program, Atlanta, Georgia, USA
- Andrew B. Conley
- Center for Integrated Genomics, Georgia Institute of Technology, Atlanta, Georgia, USA
- Lavanya Rishishwar
- Center for Integrated Genomics, Georgia Institute of Technology, Atlanta, Georgia, USA
- Suzanne E. Dale
- ACM Global Laboratories, Rochester, New York, USA
- Dwight J. Hardy
- Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
- Roberto L. Vargas
- Department of Pathology and Laboratory Medicine, Rochester General Hospital, Rochester, New York, USA
- Ghinwa Dumyati
- Infectious Diseases Division, University of Rochester Medical Center, Rochester, New York, USA
- Marion A. Kainer
- Tennessee Department of Health, Nashville, Tennessee, USA
- Erin C. Phipps
- University of New Mexico, Albuquerque, New Mexico, USA
- Rebecca Pierce
- Public Health Division, Oregon Health Authority, Salem, Oregon, USA
- Lucy E. Wilson
- Maryland Department of Health and Mental Hygiene, Baltimore, Maryland, USA
- Matthew Sorensen
- Pataigin, LLC, Seattle, Washington, USA
- Erik Nilsson
- Pataigin, LLC, Seattle, Washington, USA
- I. King Jordan
- ORCiD
- Center for Integrated Genomics, Georgia Institute of Technology, Atlanta, Georgia, USA
- Eileen M. Burd
- ORCiD
- Emory Antibiotic Resistance Center, Atlanta, Georgia, USA
- Monica M. Farley
- Emory Antibiotic Resistance Center, Atlanta, Georgia, USA
- Jesse T. Jacob
- ORCiD
- Emory Antibiotic Resistance Center, Atlanta, Georgia, USA
- Robert K. Ernst
- ORCiD
- Department of Microbial Pathogenesis, University of Maryland—Baltimore, Baltimore, Maryland, USA
- David S. Weiss
- ORCiD
- Emory Vaccine Center, Atlanta, Georgia, USA
- DOI
- https://doi.org/10.1128/mBio.02881-20
- Journal volume & issue
-
Vol. 12,
no. 1
Abstract
Heteroresistance is an underappreciated phenomenon that may be the cause of some unexplained antibiotic treatment failures. Misclassification of heteroresistant isolates as susceptible may lead to inappropriate therapy.
