Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Abstract

Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins.