Temporal trends in lipid testing among children and adolescents: A population based study

Abstract

Unfavorable lipid levels during childhood are associated with subsequent development of atherosclerotic cardiovascular disease. The American Academy of Pediatrics and National Heart, Lung and Blood Institute in 2011 recommended universal lipid screening for children between ages 9–11years and between ages 17–21years. The objective of the study was to determine temporal trends in lipid testing among children and young adults in a mid-western population. The Rochester Epidemiology Project database was used to identify lipid testing in ages 2–21years (n=51,176) in the Olmsted County population from January 1, 2008 through December 31, 2014. Generalized estimating equations with Poisson distribution were used to test for temporal trends in lipid testing across the age groups. There was modest increase in lipid testing in children in the age groups, 9–11years and 17–21years (1.5% in 2008 to 2.2% in 2014, P<0.001 and 4.4% in 2008 to 4.6% in 2014, P=0.02, respectively). There was a significant decrease in proportion of 17–21year olds with elevated total cholesterol (16.2% in 2008 to 11.6% in 2014; P=0.01) and non-high density lipoprotein cholesterol (22.6% in 2008 to 12.6% in 2014; P<0.001). In this population-based study, rates of lipid testing increased minimally only in the last six years. Further longitudinal studies are warranted to improve guideline dissemination and address attitudes, practices and barriers to lipid testing in children and young adults. Keywords: Lipids, Screening, Children, Dyslipidemia, Hypercholesterolemia