Preliminary study of dysembryoplastic neuroepithelial tumor in relationship between its MRI types and epilepsy control following tumor removal

Abstract

Objective To explore the relationship between MRI types and epilepsy control following tumor removal of dysembryoplastic neuroepithelial tumor (DNT). Methods The clinical and follow ⁃ up data of DNT cases were retrospectively collected from January 2012 to July 2019, and the data were further analyzed with respect to prognostic factors. Results Epilepsy occurred in all cases. According to MRI⁃based classification, 8 patients belonged to type Ⅰ, 4 patients were type Ⅱ, and the other 2 patients were type Ⅲ. Tumor total removal was performed in all cases. Postoperative pathological HE staining confirmed each tumor simple contained specific neuronal components in all cases, and in 13 cases, synaptin (Syn), oligodendrocyte transcription factor 2 (Olig ⁃ 2) and neuronal nuclear antigen (NeuN) were positive in routine immunohistochemical staining. In the postoperative follow ⁃up period from 6-84 months, Engel Ⅰ outcome was achieved in all type Ⅰ cases and 2 type Ⅱ cases, Engel Ⅲ was in 2 type Ⅱ cases, Engel Ⅱ was in 2 type Ⅲ cases. Conclusions Postoperative seizure control in PNT may be closely associated with the MRI types, and type Ⅰ may have a better prognosis in seizure control following tumor removal than type Ⅱ and type Ⅲ. DOI：10.3969/j.issn.1672⁃6731.2020.03.014

Keywords

• neoplasms, neuroepithelial
• magnetic resonance imaging
• epilepsy