Endothelial dysfunction. Do we understand this term properly?

Abstract

The objective: to clarify the limits of using the term of endothelial dysfunction in research and clinical work.Results: the concept of endothelial dysfunction has become ingrained in research activities while in clinical work, it is used rarely and fairly often inadequately. It is recommended that endothelial dysfunction should be understood as a persistent change in the structure and/or functional activity of endothelium resulting in vascular tone disorders, thrombosis and other complications. The concept of "dysfunction" and "activation" of epithelium should be differentiated. One means the injury, the other reflects changes in response to various provocative effects. The markers of endothelial dysfunction (instrumental and biochemical) and ways of its management with certain pharmacological agents (antioxidants, NADP-oxydases inhibitors, etc.) have been discussed.

Keywords

• дисфункция эндотелия
• методы диагностики
• таргетная терапия эндотелия