Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo

Abstract

Parkinson’s disease: Preventing neuron death A drug that activates a neuron-protecting protein in the brain may help treat Parkinson’s disease (PD). Scientists believe neurons die during PD because of an over-activation of proinflammatory markers within immune cell populations, such as the microglia and macrophage cells found in the central nervous system and the brain. Now, Byung Kwan Jin at Kyung Hee University in Seoul and Won-Ho Shin at the Korea Institute of Toxicology in Daejeon and co-workers have demonstrated that a proinflammatory state can be reversed in rat PD models by administering capsaicin, an analgesic drug. Capsaicin activates a receptor protein that is highly expressed in neurons, microglia and astrocytes, and may play a role in neuronal function and motor control. The protein activation reversed the inflammatory state of the immune cells, providing a more protective environment for neurons.