Amination based on the system of ammonium formate-Pd/C(甲酸铵-Pd/C体系进行胺化反应的研究)

DAILi-yan(戴立言); HUSi-jun(胡斯军); YINSheng(尹胜); WANGXiao-zhong(王晓钟); CHENYing-qi(陈英奇)

doi:10.3785/j.issn.1008-9497.2013.02.009

Zhejiang Daxue xuebao. Lixue ban (Mar 2013)

Amination based on the system of ammonium formate-Pd/C(甲酸铵-Pd/C体系进行胺化反应的研究)

DAILi-yan(戴立言),
HUSi-jun(胡斯军),
YINSheng(尹胜),
WANGXiao-zhong(王晓钟),
CHENYing-qi(陈英奇)

Affiliations

DAILi-yan(戴立言): Institute of Pharmaceutical Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学制药工程研究所，浙江　杭州　310027)
HUSi-jun(胡斯军): Institute of Pharmaceutical Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学制药工程研究所，浙江　杭州　310027)
YINSheng(尹胜): Institute of Pharmaceutical Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学制药工程研究所，浙江　杭州　310027)
WANGXiao-zhong(王晓钟): Institute of Pharmaceutical Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学制药工程研究所，浙江　杭州　310027)
CHENYing-qi(陈英奇): Institute of Pharmaceutical Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学制药工程研究所，浙江　杭州　310027)

DOI: https://doi.org/10.3785/j.issn.1008-9497.2013.02.009
Journal volume & issue: Vol. 40, no. 2
pp. 161 – 165

Abstract

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介绍了一种用于羰基胺化的合成方法.该方法以酮为底物，HCOONH4为氢源和氮源，Pd/C为催化剂，CH3OH与H2O为溶剂，对羰基进行还原胺化制得相应的胺.甲酸铵作为氢供体，具有廉价、易得、还原性能好等优点，Pd/C催化加氢可使反应在温和的条件下进行.该方法反应速度快、后处理方便、选择性好.最佳反应条件：常温常压、CH3OH：H2O(V：V) = 9：1、HCOONH4：原料：Pd/C(M：M： M） = 100：10：1.实验过程中，分别对2-金刚烷酮；5-氨基羟基-2-金刚烷酮；3-奎宁酮进行了胺化反应研究，获得较好的结果，产物均经1H-NMR、GC-MS或MS确证结构.

Published in Zhejiang Daxue xuebao. Lixue ban

ISSN: 1008-9497 (Print)
Publisher: Zhejiang University Press
Country of publisher: China
LCC subjects: Science: Mathematics: Instruments and machines: Electronic computers. Computer science; Science: Physics
Website: https://www.zjujournals.com/sci/EN/1008-9497/home.shtml

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