Nature Communications (Nov 2022)
Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
- Han Luo,
- Xuyang Xia,
- Li-Bin Huang,
- Hyunsu An,
- Minyuan Cao,
- Gyeong Dae Kim,
- Hai-Ning Chen,
- Wei-Han Zhang,
- Yang Shu,
- Xiangyu Kong,
- Zhixiang Ren,
- Pei-Heng Li,
- Yang Liu,
- Huairong Tang,
- Ronghao Sun,
- Chao Li,
- Bing Bai,
- Weiguo Jia,
- Yi Liu,
- Wei Zhang,
- Li Yang,
- Yong Peng,
- Lunzhi Dai,
- Hongbo Hu,
- Yong Jiang,
- Yiguo Hu,
- Jingqiang Zhu,
- Hong Jiang,
- Zhihui Li,
- Carlos Caulin,
- Jihwan Park,
- Heng Xu
Affiliations
- Han Luo
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Xuyang Xia
- Division of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University
- Li-Bin Huang
- Department of General Surgery, West China Hospital, Sichuan University
- Hyunsu An
- School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
- Minyuan Cao
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Gyeong Dae Kim
- School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
- Hai-Ning Chen
- Department of General Surgery, West China Hospital, Sichuan University
- Wei-Han Zhang
- Department of General Surgery, West China Hospital, Sichuan University
- Yang Shu
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Xiangyu Kong
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Zhixiang Ren
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Pei-Heng Li
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Yang Liu
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Huairong Tang
- Health Promotion Center, West China Hospital, Sichuan University
- Ronghao Sun
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Chao Li
- Department of Head and Neck Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China
- Bing Bai
- State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology; Yunnan Key Laboratory of Primate Biomedical Research
- Weiguo Jia
- Center for Geriatrics medicine, West China Hospital, Sichuan University
- Yi Liu
- Division of Rheumatism & Immunology, Rare Diseases Center, West Chia Hospital, Sichuan University
- Wei Zhang
- Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University
- Li Yang
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Yong Peng
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Lunzhi Dai
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Hongbo Hu
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Yong Jiang
- Division of Pathology, West China Hospital, Sichuan University
- Yiguo Hu
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Jingqiang Zhu
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Hong Jiang
- State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Zhihui Li
- Division of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University
- Carlos Caulin
- Department of Otolaryngology - Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona
- Jihwan Park
- School of Life Sciences, Gwangju Institute of Science and Technology (GIST)
- Heng Xu
- Division of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-022-34395-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Cancer-associated fibroblasts (CAFs) are a predominant and critical component of the tumour microenvironment. Here, the authors integrate and analyse single-cell RNA-seq data of CAFs across 10 common solid cancer types, identifying their plasticity and interactions with other cell types.
