Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

Abstract

Interorganelle membrane contact sites between the endoplasmic reticulum and the endolysosome. Here, the authors show that ER-endolysosome membrane contact sites are promoted by the proteins protrudin and PDZD8 and may contribute to lipid extraction at these contact sites.