EMBO Molecular Medicine (Jan 2021)
Immunodynamics of explanted human tumors for immuno‐oncology
- Agathe Dubuisson,
- Jean‐Eudes Fahrner,
- Anne‐Gaëlle Goubet,
- Safae Terrisse,
- Nicolas Voisin,
- Charles Bayard,
- Sebastien Lofek,
- Damien Drubay,
- Delphine Bredel,
- Séverine Mouraud,
- Sandrine Susini,
- Alexandria Cogdill,
- Lucas Rebuffet,
- Elise Ballot,
- Nicolas Jacquelot,
- Vincent Thomas de Montpreville,
- Odile Casiraghi,
- Camélia Radulescu,
- Sophie Ferlicot,
- David J Figueroa,
- Sapna Yadavilli,
- Jeremy D Waight,
- Marc Ballas,
- Axel Hoos,
- Thomas Condamine,
- Bastien Parier,
- Christophe Gaudillat,
- Bertrand Routy,
- François Ghiringhelli,
- Lisa Derosa,
- Ingrid Breuskin,
- Mathieu Rouanne,
- Fabrice André,
- Cédric Lebacle,
- Hervé Baumert,
- Marie Wislez,
- Elie Fadel,
- Isabelle Cremer,
- Laurence Albiges,
- Birgit Geoerger,
- Jean‐Yves Scoazec,
- Yohann Loriot,
- Guido Kroemer,
- Aurélien Marabelle,
- Mélodie Bonvalet,
- Laurence Zitvogel
Affiliations
- Agathe Dubuisson
- Institut Gustave Roussy Villejuif France
- Jean‐Eudes Fahrner
- Institut Gustave Roussy Villejuif France
- Anne‐Gaëlle Goubet
- Institut Gustave Roussy Villejuif France
- Safae Terrisse
- Institut Gustave Roussy Villejuif France
- Nicolas Voisin
- Institut Gustave Roussy Villejuif France
- Charles Bayard
- Institut Gustave Roussy Villejuif France
- Sebastien Lofek
- Institut Gustave Roussy Villejuif France
- Damien Drubay
- Institut Gustave Roussy Villejuif France
- Delphine Bredel
- Institut Gustave Roussy Villejuif France
- Séverine Mouraud
- Institut Gustave Roussy Villejuif France
- Sandrine Susini
- Institut Gustave Roussy Villejuif France
- Alexandria Cogdill
- Institut Gustave Roussy Villejuif France
- Lucas Rebuffet
- Institut Gustave Roussy Villejuif France
- Elise Ballot
- Cancer Biology Transfer Platform Centre Georges‐François Leclerc Dijon France
- Nicolas Jacquelot
- Institut Gustave Roussy Villejuif France
- Vincent Thomas de Montpreville
- Service d'Anatomie et cytologie pathologiques Hôpital Marie Lannelongue Le Plessis‐Robinson France
- Odile Casiraghi
- Departement de Biologie et Pathologie Médicales Gustave Roussy Cancer Campus Villejuif France
- Camélia Radulescu
- Service d'Anatomie et cytologie pathologiques Hôpital Foch Suresnes France
- Sophie Ferlicot
- Service d'Anatomie et cytologie pathologiques Hôpital Bicêtre Le Kremlin‐Bicêtre France
- David J Figueroa
- Oncology R&D GlaxoSmithKline, Collegeville PA USA
- Sapna Yadavilli
- Oncology R&D GlaxoSmithKline, Collegeville PA USA
- Jeremy D Waight
- Oncology R&D GlaxoSmithKline, Collegeville PA USA
- Marc Ballas
- Oncology R&D GlaxoSmithKline, Collegeville PA USA
- Axel Hoos
- Oncology R&D GlaxoSmithKline, Collegeville PA USA
- Thomas Condamine
- Incyte Research Institute Wilmington DE USA
- Bastien Parier
- Service de Chirurgie urologique Hôpital Bicêtre Le Kremlin‐Bicêtre France
- Christophe Gaudillat
- Service d'Urologie Hôpital Saint Joseph Paris France
- Bertrand Routy
- Division of Oncology Department of Medicine Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM) Montréal QC Canada
- François Ghiringhelli
- Cancer Biology Transfer Platform Centre Georges‐François Leclerc Dijon France
- Lisa Derosa
- Institut Gustave Roussy Villejuif France
- Ingrid Breuskin
- Département de Chirurgie Gustave RoussyUniversité Paris‐Saclay Villejuif France
- Mathieu Rouanne
- Institut Gustave Roussy Villejuif France
- Fabrice André
- Institut Gustave Roussy Villejuif France
- Cédric Lebacle
- Service de Chirurgie urologique Hôpital Bicêtre Le Kremlin‐Bicêtre France
- Hervé Baumert
- Institut Gustave Roussy Villejuif France
- Marie Wislez
- AP‐HP Centre – Université de Paris Hôpital Cochin Unité d'Oncologie ThoraciqueService de Pneumologie Paris France
- Elie Fadel
- Service de Chirurgie Thoracique Hôpital Marie Lannelongue Le Plessis‐Robinson France
- Isabelle Cremer
- Team Inflammation, Complement and Cancer INSERMCentre de Recherche des Cordeliers Paris France
- Laurence Albiges
- Institut Gustave Roussy Villejuif France
- Birgit Geoerger
- Department of Pediatric and Adolescent Oncology Gustave Roussy Cancer CampusUniversité Paris‐Saclay Villejuif France
- Jean‐Yves Scoazec
- Institut Gustave Roussy Villejuif France
- Yohann Loriot
- Institut Gustave Roussy Villejuif France
- Guido Kroemer
- Institut Gustave Roussy Villejuif France
- Aurélien Marabelle
- Institut Gustave Roussy Villejuif France
- Mélodie Bonvalet
- Institut Gustave Roussy Villejuif France
- Laurence Zitvogel
- Institut Gustave Roussy Villejuif France
- DOI
- https://doi.org/10.15252/emmm.202012850
- Journal volume & issue
-
Vol. 13,
no. 1
pp. n/a – n/a
Abstract
Abstract Decision making in immuno‐oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno‐assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti‐PD‐1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay.
Keywords