Разработка и регистрация лекарственных средств (Jan 2019)

FEATURES ENZYMATIC RELEASE BIOCOMPATIBLE MICROCAPSULES WITH BUILT-IN SHELL INHIBITOR PEPTIDASE

  • E. V. Popova,
  • P. P. Beltiukov,
  • V. A. Kuznetsov,
  • S. G. Petunov,
  • A. S. Radilov

Journal volume & issue
Vol. 0, no. 1
pp. 52 – 57

Abstract

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Microcapsules consisted of biocompatible components- bovine serum albumin and tannic acid were made using Layer-by-Layer encapsulation method. Process of microcapsule formation was studied. Poly(allyl)amine hydrochloride (PAH) was included into the microcapsules and process of its release into medium with neutral and alkaline pH and trypsin was studied. The ability to control release of model substance PAH from these capsules with the help of trypsin was shown.

Keywords