eLife (2021-04-01)

Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

  • Mahmood S Hoseini,
  • Bryan Higashikubo,
  • Frances S Cho,
  • Andrew H Chang,
  • Alexandra Clemente-Perez,
  • Irene Lew,
  • Agnieszka Ciesielska,
  • Michael P Stryker,
  • Jeanne T Paz

DOI
https://doi.org/10.7554/eLife.61437
Journal volume & issue
Vol. 10

Abstract

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Visual perception in natural environments depends on the ability to focus on salient stimuli while ignoring distractions. This kind of selective visual attention is associated with gamma activity in the visual cortex. While the nucleus reticularis thalami (nRT) has been implicated in selective attention, its role in modulating gamma activity in the visual cortex remains unknown. Here, we show that somatostatin- (SST) but not parvalbumin-expressing (PV) neurons in the visual sector of the nRT preferentially project to the dorsal lateral geniculate nucleus (dLGN), and modulate visual information transmission and gamma activity in primary visual cortex (V1). These findings pinpoint the SST neurons in nRT as powerful modulators of the visual information encoding accuracy in V1 and represent a novel circuit through which the nRT can influence representation of visual information.

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