Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

• Sai Pradeep Velagapudi,
• Yiling Luo,
• Tuan Tran,
• Hafeez S. Haniff,
• Yoshio Nakai,
• Mohammad Fallahi,
• Gustavo J. Martinez,
• Jessica L. Childs-Disney,
• Matthew D. Disney

Affiliations

Sai Pradeep Velagapudi

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States

Yiling Luo

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States

Tuan Tran

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States

Hafeez S. Haniff

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States

Yoshio Nakai

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States

Mohammad Fallahi

§Informatics Core, The Scripps Research Institute, Jupiter, Florida, United States

Gustavo J. Martinez

∥Genomics Core, The Scripps Research Institute, Jupiter, Florida, United States

Jessica L. Childs-Disney

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States

Matthew D. Disney

†Department of Chemistry, The Scripps Research Institute, Jupiter, Florida, United States