Nature Communications (Jul 2021)
Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis
Abstract
Cranial sutures are major growth centers for the skull vault and premature fusion leads to pathological fusion, craniosynostosis. Here the authors isolate Wnt responsive skeletal stem and progenitor cells from sutures, that can be transplanted together with Wnt3a protein to repair craniosynostosis in a mouse model.