Nature Communications (Jul 2021)

Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis

  • Siddharth Menon,
  • Ankit Salhotra,
  • Siny Shailendra,
  • Ruth Tevlin,
  • Ryan C. Ransom,
  • Michael Januszyk,
  • Charles K. F. Chan,
  • Björn Behr,
  • Derrick C. Wan,
  • Michael T. Longaker,
  • Natalina Quarto

DOI
https://doi.org/10.1038/s41467-021-24801-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Cranial sutures are major growth centers for the skull vault and premature fusion leads to pathological fusion, craniosynostosis. Here the authors isolate Wnt responsive skeletal stem and progenitor cells from sutures, that can be transplanted together with Wnt3a protein to repair craniosynostosis in a mouse model.