Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity

Eoin McEvoy; Tal Sneh; Emad Moeendarbary; Yousef Javanmardi; Nadia Efimova; Changsong Yang; Gloria E. Marino-Bravante; Xingyu Chen; Jorge Escribano; Fabian Spill; José Manuel Garcia-Aznar; Ashani T. Weeraratna; Tatyana M. Svitkina; Roger D. Kamm; Vivek B. Shenoy

doi:10.1038/s41467-022-34701-y

Nature Communications (Nov 2022)

Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity

Eoin McEvoy,
Tal Sneh,
Emad Moeendarbary,
Yousef Javanmardi,
Nadia Efimova,
Changsong Yang,
Gloria E. Marino-Bravante,
Xingyu Chen,
Jorge Escribano,
Fabian Spill,
José Manuel Garcia-Aznar,
Ashani T. Weeraratna,
Tatyana M. Svitkina,
Roger D. Kamm,
Vivek B. Shenoy

Affiliations

Eoin McEvoy: Department of Materials Science and Engineering, University of Pennsylvania
Tal Sneh: Center for Engineering Mechanobiology, University of Pennsylvania
Emad Moeendarbary: Department of Mechanical Engineering, University College London
Yousef Javanmardi: Department of Mechanical Engineering, University College London
Nadia Efimova: Department of Biology, University of Pennsylvania
Changsong Yang: Department of Biology, University of Pennsylvania
Gloria E. Marino-Bravante: Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health
Xingyu Chen: Department of Materials Science and Engineering, University of Pennsylvania
Jorge Escribano: Department of Mechanical Engineering, University of Zaragoza
Fabian Spill: School of Mathematics, University of Birmingham
José Manuel Garcia-Aznar: Department of Mechanical Engineering, University of Zaragoza
Ashani T. Weeraratna: Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health
Tatyana M. Svitkina: Department of Biology, University of Pennsylvania
Roger D. Kamm: Department of Mechanical Engineering, Massachusetts Institute of Technology
Vivek B. Shenoy: Department of Materials Science and Engineering, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-022-34701-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown, recovery, and integrity of endothelial junctions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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