Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis

Manickam Kalappan Vanitha; Kalpana Deepa Priya; Kuppusamy Baskaran; Kuppusamy Periyasamy; Dhravidamani Saravanan; Ramachandran Venkateswari; Balasundaram Revathi Mani; Aruldass Ilakkia; Sundaramoorthy Selvaraj; Rajendran Menaka; Mahendran Geetha; Nadarajah Rashanthy; Pandi Anandakumar; Dhanapal Sakthisekaran

doi:10.3831/KPI.2015.18.027

Journal of Pharmacopuncture (Sep 2015)

Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis

Manickam Kalappan Vanitha,
Kalpana Deepa Priya,
Kuppusamy Baskaran,
Kuppusamy Periyasamy,
Dhravidamani Saravanan,
Ramachandran Venkateswari,
Balasundaram Revathi Mani,
Aruldass Ilakkia,
Sundaramoorthy Selvaraj,
Rajendran Menaka,
Mahendran Geetha,
Nadarajah Rashanthy,
Pandi Anandakumar,
Dhanapal Sakthisekaran

Affiliations

Manickam Kalappan Vanitha: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Kalpana Deepa Priya: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Kuppusamy Baskaran: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Kuppusamy Periyasamy: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Dhravidamani Saravanan: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Ramachandran Venkateswari: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Balasundaram Revathi Mani: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Aruldass Ilakkia: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Sundaramoorthy Selvaraj: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Rajendran Menaka: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Mahendran Geetha: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Nadarajah Rashanthy: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India
Pandi Anandakumar: Department of Biomedical Sciences, College of Health Sciences, Arsi University, Asella, Ethiopia
Dhanapal Sakthisekaran: Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India

DOI: https://doi.org/10.3831/KPI.2015.18.027
Journal volume & issue: Vol. 18, no. 3
pp. 68 – 74

Abstract

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Objectives: The present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and electron transport chain enzymes during 7,12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in Sprague-Dawley rats. Methods: Animals in which breast cancer had been induced by using DMBA (25 mg/kg body weight) showed an increase in mitochondrial LPO together with decreases in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, and vitamin E), in citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha ketoglutarate dehydrogenase (alpha KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and in electron transport chain (ETC) complexes. Results: Taurine (100 mg/kg body weight) treatment decreased liver mitochondrial LPO and augmented the activities/levels of enzymic, and non-enzymic antioxidants, tricarboxylic acid cycle enzymes and ETC complexes. Conclusion: The results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas.

Published in Journal of Pharmacopuncture

ISSN: 2093-6966 (Print); 2234-6856 (Online)
Publisher: Korean Pharmacopuncture Institute
Country of publisher: Korea, Republic of
LCC subjects: Medicine: Other systems of medicine: Miscellaneous systems and treatments; Medicine: Therapeutics. Pharmacology
Website: http://www.journal-jop.org/main.html

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