Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

Jieun Kim; Hyebin Koh; Xing Zhen; Dong-Seok Lee; Hye-Yeong Ha; Jong-Hee Lee

Stem Cell Research (Mar 2021)

Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

Jieun Kim,
Hyebin Koh,
Xing Zhen,
Dong-Seok Lee,
Hye-Yeong Ha,
Jong-Hee Lee

Affiliations

Jieun Kim: Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Hyebin Koh: Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea
Xing Zhen: School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea
Dong-Seok Lee: School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea
Hye-Yeong Ha: Division of Intractable Disease Research, Korea National Institute of Health, Cheongju, Republic of Korea; Corresponding author.
Jong-Hee Lee: National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Corresponding author.

Journal volume & issue: Vol. 51
p. 102199

Abstract

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Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD−) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD− sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD− somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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