Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt

Huang Nanqu; Huang Juan; Zhang Ying; Chen Mingji; Shi Jingshan; Jin Feng

doi:10.1515/tnsci-2020-0165

Translational Neuroscience (Apr 2021)

Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt

Huang Nanqu,
Huang Juan,
Zhang Ying,
Chen Mingji,
Shi Jingshan,
Jin Feng

Affiliations

Huang Nanqu: Drug Clinical Trial Institution, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), No. 98, Fenghuang Road, Zunyi 563000, Guizhou, China
Huang Juan: Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, No. 280, South Chongqing Road, Shanghai 200025, China
Zhang Ying: Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, No. 6, Xuefu West Road, Xinpu New District, Zunyi 563000, Guizhou, China
Chen Mingji: Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, No. 6, Xuefu West Road, Xinpu New District, Zunyi 563000, Guizhou, China
Shi Jingshan: Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, No. 6, Xuefu West Road, Xinpu New District, Zunyi 563000, Guizhou, China
Jin Feng: Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, No. 6, Xuefu West Road, Xinpu New District, Zunyi 563000, Guizhou, China

DOI: https://doi.org/10.1515/tnsci-2020-0165
Journal volume & issue: Vol. 12, no. 1
pp. 138 – 144

Abstract

Read online

Our previous in vivo study found that resveratrol (Res), which is a phytoalexin, attenuated 6-hydroxydopamine (6-OHDA)-induced motor dysfunction by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in rats. Therefore, we further explored the protective effect of Res on 6-OHDA-induced damage to PC12 cells in vitro with respect to the PI3K/Akt signaling pathway.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

About the journal

Abstract

Keywords