International Journal of Infectious Diseases (Oct 2021)

Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam

  • Nguyen Van Vinh Chau,
  • Le Nguyen Thanh Nhan,
  • Lam Anh Nguyet,
  • Nguyen Thi Kha Tu,
  • Nguyen Thi Thu Hong,
  • Dinh Nguyen Huy Man,
  • Dinh Thi Bich Ty,
  • Le Nguyen Truc Nhu,
  • Lam Minh Yen,
  • Truong Huu Khanh,
  • Du Tuan Quy,
  • Ngo Ngoc Quang Minh,
  • Nguyen Thi Han Ny,
  • Danielle Anderson,
  • Lin-Fa Wang,
  • H. Rogier van Doorn,
  • Nguyen Thanh Hung,
  • Tran Tan Thanh,
  • Guy Thwaites,
  • Le Van Tan

Journal volume & issue
Vol. 111
pp. 127 – 129

Abstract

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We tested pre-pandemic (2015–-2019) plasma samples from 148 Vietnamese children and 100 Vietnamese adults at high risk of zoonotic infections for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated no evidence of prior serological cross-reactivity with SARS-CoV-2 that might explain the low numbers of COVID-19 in Vietnam. No pre-existing cross-reactivity might explain Vietnam success of COVID-19 control.

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