Nature Communications (Nov 2017)
DNA methylation at enhancers identifies distinct breast cancer lineages
- Thomas Fleischer,
- Xavier Tekpli,
- Anthony Mathelier,
- Shixiong Wang,
- Daniel Nebdal,
- Hari P. Dhakal,
- Kristine Kleivi Sahlberg,
- Ellen Schlichting,
- Oslo Breast Cancer Research Consortium (OSBREAC),
- Anne-Lise Børresen-Dale,
- Elin Borgen,
- Bjørn Naume,
- Ragnhild Eskeland,
- Arnoldo Frigessi,
- Jörg Tost,
- Antoni Hurtado,
- Vessela N. Kristensen
Affiliations
- Thomas Fleischer
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Xavier Tekpli
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Anthony Mathelier
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Shixiong Wang
- Centre for Molecular Medicine Norway (NCMM), University of Oslo
- Daniel Nebdal
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Hari P. Dhakal
- Department of Pathology, Oslo University Hospital
- Kristine Kleivi Sahlberg
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Ellen Schlichting
- Department of Oncology, Oslo University Hospital
- Oslo Breast Cancer Research Consortium (OSBREAC)
- Anne-Lise Børresen-Dale
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Elin Borgen
- Department of Pathology, Oslo University Hospital
- Bjørn Naume
- Department of Oncology, Oslo University Hospital
- Ragnhild Eskeland
- Department of Biosciences, University of Oslo
- Arnoldo Frigessi
- Department of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, University of Oslo and Research Support Services, Oslo University Hospital
- Jörg Tost
- Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA–Institut de Génomique
- Antoni Hurtado
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- Vessela N. Kristensen
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00510-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers able to separate specific breast cancer subtypes.
