Diabetes, Metabolic Syndrome and Obesity (Jun 2023)
Ferroptosis and Traditional Chinese Medicine for Type 2 Diabetes Mellitus
Abstract
Dandan Xie,1– 3,* Kai Li,1,* Ruxue Feng,4,* Man Xiao,5 Zhifeng Sheng,2 Yiqiang Xie1 1College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, Health Management Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 3Department of Clinical Nutrition, the First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, People’s Republic of China; 4Department of Stomatology, Geriatric Hospital of Hainan, Haikou, Hainan, People’s Republic of China; 5Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, Hainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiqiang Xie, College of Traditional Chinese Medicine, Hainan Medical University, No. 3, Xueyuan Road, Haikou, Hainan, 571199, People’s Republic of China, Tel +86 13036001921, Email [email protected] Zhifeng Sheng, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, Health Management Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China, Tel +86 13574806523, Email [email protected]: Ferroptosis, an emerging form of regulated programmed cell death, has garnered significant attention in the past decade. It is characterized by the accumulation of lipid peroxides and subsequent damage to cellular membranes, which is dependent on iron. Ferroptosis has been implicated in the pathogenesis of various diseases, including tumors and diabetes mellitus. Traditional Chinese medicine (TCM) has unique advantages in preventing and treating type 2 diabetes mellitus (T2DM) due to its anti-inflammatory, antioxidant, immunomodulatory, and intestinal flora-regulating functions. Recent studies have determined that TCM may exert therapeutic effects on T2DM and its complications by modulating the ferroptosis-related pathways. Therefore, a comprehensive and systematic understanding of the role of ferroptosis in the pathogenesis and TCM treatment of T2DM is of great significance for developing therapeutic drugs for T2DM and enriching the spectrum of effective T2DM treatment with TCM. In this review, we review the concept, mechanism, and regulatory pathways of ferroptosis and the ferroptosis mechanism of action involved in the development of T2DM. Also, we develop a search strategy, establish strict inclusion and exclusion criteria, and summarize and analyze the application of the ferroptosis mechanism in TCM studies related to T2DM and its complications. Finally, we discuss the shortcomings of current studies and propose a future research focus.Keywords: ferroptosis, traditional Chinese medicine, type 2 diabetes mellitus, complications
