Revista da Sociedade Brasileira de Medicina Tropical ()

Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

  • Priscila Marques de Macedo,
  • Rodrigo Almeida-Paes,
  • Marcos de Abreu Almeida,
  • Rowena Alves Coelho,
  • Marcio Amaral de Oliveira Filho,
  • Denise Machado Medeiros,
  • Adriano Gomes-Silva,
  • Jéssica Ribeiro de Lima,
  • Alda Maria Da-Cruz,
  • Rosely Maria Zancopé-Oliveira,
  • Antonio Carlos Francesconi do Valle

DOI
https://doi.org/10.1590/0037-8682-0318-2017
Journal volume & issue
Vol. 51, no. 1
pp. 111 – 114

Abstract

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Abstract The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.

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