Application of High-Resolution Terahertz Gas Spectroscopy for Studying the Composition of Thermal Decomposition Products in Human Urine of Prostate Cancer Patients

Abstract

The results of using nonstationary high-resolution THz spectroscopy for detecting a characteristic set of metabolites of thermal decomposition products of urine from prostate cancer patients, aimed at identifying specific markers, are presented. Studies of the composition of biological fluid in prostate cancer were carried out using 12 urine samples from cancer patients and 4 samples from conditionally healthy volunteers. Differences in the composition and content of substances in the urine samples of cancer patients compared to the urine of conditionally healthy volunteers were identified, which allows preliminary conclusions to be drawn about substances promising for use as markers of prostate cancer in urine. The presented approach is promising for developing a method for noninvasive study of the composition of biological fluids, which makes it possible to identify metabolite markers of various pathologies and diseases.

Keywords

• THz high-resolution spectroscopy
• prostate cancer
• urina
• prostate-specific antigen
• thermal decomposition
• metabolite