Changes in some indexes of protein homeostasis and pro-oxidant protection in the oral fluid of young people with periodontitis under the influence of the proposed complex therapy

Abstract

Periodontal diseases comprise an actual problem nowadays due to their high prevalence. Young people in particularly remain susceptible to aggressive periodontal disorders that affect the suspensory apparatus of the teeth. The aim of the study was to establish some indexes of protein peroxidation and total protein content in the oral liquid of young people affected by stage I periodontitis, degree A and B observed before and after the appointed complex therapy. Conducted investigations demonstrate that there are significant changes in protein homeostasis and pro-oxidant protection in the oral liquid of young people in case of stage I periodontitis, degree A and B. The latter indicates an increase of the total protein content as well as a rise of oxidative protein modifications of both aldehyde and ketone derivatives, which are neutral and basic in nature. The recorded dynamic of the gained results of protein metabolism and pro-oxidant protection in the oral liquid of young people in case stage I periodontitis, degree A and B obtained at different terms after administered treatment suggests that the introduced management provides a pronounced positive effect on the regulation of these indexes. Moreover, herbal remedies as a part of the proposed agents for local and general administration show a good antioxidant effect and contribute to long-term maintenance of gained results. They also prevent recurrence of periodontitis and contribute to prolonged remission.