Nature Communications (Mar 2020)
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis
- Jingyuan Xie,
- Lili Liu,
- Nikol Mladkova,
- Yifu Li,
- Hong Ren,
- Weiming Wang,
- Zhao Cui,
- Li Lin,
- Xiaofan Hu,
- Xialian Yu,
- Jing Xu,
- Gang Liu,
- Yasar Caliskan,
- Carlo Sidore,
- Olivia Balderes,
- Raphael J. Rosen,
- Monica Bodria,
- Francesca Zanoni,
- Jun Y. Zhang,
- Priya Krithivasan,
- Karla Mehl,
- Maddalena Marasa,
- Atlas Khan,
- Fatih Ozay,
- Pietro A. Canetta,
- Andrew S. Bomback,
- Gerald B. Appel,
- Simone Sanna-Cherchi,
- Matthew G. Sampson,
- Laura H. Mariani,
- Agnieszka Perkowska-Ptasinska,
- Magdalena Durlik,
- Krzysztof Mucha,
- Barbara Moszczuk,
- Bartosz Foroncewicz,
- Leszek Pączek,
- Ireneusz Habura,
- Elisabet Ars,
- Jose Ballarin,
- Laila-Yasmin Mani,
- Bruno Vogt,
- Savas Ozturk,
- Abdülmecit Yildiz,
- Nurhan Seyahi,
- Hakki Arikan,
- Mehmet Koc,
- Taner Basturk,
- Gonca Karahan,
- Sebahat Usta Akgul,
- Mehmet Sukru Sever,
- Dan Zhang,
- Domenico Santoro,
- Mario Bonomini,
- Francesco Londrino,
- Loreto Gesualdo,
- Jana Reiterova,
- Vladimir Tesar,
- Claudia Izzi,
- Silvana Savoldi,
- Donatella Spotti,
- Carmelita Marcantoni,
- Piergiorgio Messa,
- Marco Galliani,
- Dario Roccatello,
- Simona Granata,
- Gianluigi Zaza,
- Francesca Lugani,
- GianMarco Ghiggeri,
- Isabella Pisani,
- Landino Allegri,
- Ben Sprangers,
- Jin-Ho Park,
- BeLong Cho,
- Yon Su Kim,
- Dong Ki Kim,
- Hitoshi Suzuki,
- Antonio Amoroso,
- Daniel C. Cattran,
- Fernando C. Fervenza,
- Antonello Pani,
- Patrick Hamilton,
- Shelly Harris,
- Sanjana Gupta,
- Chris Cheshire,
- Stephanie Dufek,
- Naomi Issler,
- Ruth J. Pepper,
- John Connolly,
- Stephen Powis,
- Detlef Bockenhauer,
- Horia C. Stanescu,
- Neil Ashman,
- Ruth J. F. Loos,
- Eimear E. Kenny,
- Matthias Wuttke,
- Kai-Uwe Eckardt,
- Anna Köttgen,
- Julia M. Hofstra,
- Marieke J. H. Coenen,
- Lambertus A. Kiemeney,
- Shreeram Akilesh,
- Matthias Kretzler,
- Lawrence H. Beck,
- Benedicte Stengel,
- Hanna Debiec,
- Pierre Ronco,
- Jack F. M. Wetzels,
- Magdalena Zoledziewska,
- Francesco Cucca,
- Iuliana Ionita-Laza,
- Hajeong Lee,
- Elion Hoxha,
- Rolf A. K. Stahl,
- Paul Brenchley,
- Francesco Scolari,
- Ming-hui Zhao,
- Ali G. Gharavi,
- Robert Kleta,
- Nan Chen,
- Krzysztof Kiryluk
Affiliations
- Jingyuan Xie
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Lili Liu
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Nikol Mladkova
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Yifu Li
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Hong Ren
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Weiming Wang
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Zhao Cui
- Renal Division, Department of Medicine, Peking University First Hospital
- Li Lin
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Xiaofan Hu
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Xialian Yu
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Jing Xu
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Gang Liu
- Renal Division, Department of Medicine, Peking University First Hospital
- Yasar Caliskan
- Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul University
- Carlo Sidore
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche
- Olivia Balderes
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Raphael J. Rosen
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Monica Bodria
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Francesca Zanoni
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Jun Y. Zhang
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Priya Krithivasan
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Karla Mehl
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Maddalena Marasa
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Atlas Khan
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Fatih Ozay
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Pietro A. Canetta
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Andrew S. Bomback
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Gerald B. Appel
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Simone Sanna-Cherchi
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Matthew G. Sampson
- Department of Pediatrics-Nephrology, University of Michigan School of Medicine
- Laura H. Mariani
- Division of Nephrology, Department of Medicine, University of Michigan
- Agnieszka Perkowska-Ptasinska
- Department of Transplantology, Nephrology and Internal Diseases, Medical University of Warsaw
- Magdalena Durlik
- Department of Transplantology, Nephrology and Internal Diseases, Medical University of Warsaw
- Krzysztof Mucha
- Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw
- Barbara Moszczuk
- Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw
- Bartosz Foroncewicz
- Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw
- Leszek Pączek
- Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw
- Ireneusz Habura
- Department of Nephrology, University Hospital of Karol Marcinkowski in Zielona Góra
- Elisabet Ars
- Molecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII
- Jose Ballarin
- Molecular Biology Laboratory and Nephrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, REDINREN, IISCIII
- Laila-Yasmin Mani
- Department of Nephrology and Hypertension, Bern University Hospital, University of Bern
- Bruno Vogt
- Department of Nephrology and Hypertension, Bern University Hospital, University of Bern
- Savas Ozturk
- Nephrology Clinic, Haseki Training and Research Hospital
- Abdülmecit Yildiz
- Department of Nephrology, Uludag University Faculty of Medicine
- Nurhan Seyahi
- Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University - Cerrahpasa
- Hakki Arikan
- Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine
- Mehmet Koc
- Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine
- Taner Basturk
- Department of Nephrology, Sisli Hamidiye Etfal Training and Research Hospital
- Gonca Karahan
- Department of Medical Biology, Istanbul School of Medicine, Istanbul University
- Sebahat Usta Akgul
- Department of Medical Biology, Istanbul School of Medicine, Istanbul University
- Mehmet Sukru Sever
- Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul University
- Dan Zhang
- Department of Nephrology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Domenico Santoro
- Department of Cinical and Experimental Medicine, Unit of Nephrology, University of Messina
- Mario Bonomini
- Department of Medicine, University of Chieti-Pescara, SS. Annunziata Hospital
- Francesco Londrino
- S. Andrea Hospital
- Loreto Gesualdo
- University of Bari
- Jana Reiterova
- Department of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University
- Vladimir Tesar
- Department of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University
- Claudia Izzi
- Second Division of Nephrology, ASST-Spedali Civili di Brescia Presidio di Montichiari
- Silvana Savoldi
- Unit of Nephrology and Dialysis ASL TO4
- Donatella Spotti
- San Raffaele Hospital
- Carmelita Marcantoni
- Cannizzaro Hospital
- Piergiorgio Messa
- Nephrology Dialysis and Kidney Transplant Unit, Fundazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli studi di Milano
- Marco Galliani
- Sandro Pertini Hospital
- Dario Roccatello
- San Giovanni Bosco Hospital (ERK-net Member) and University of Turin
- Simona Granata
- Renal Unit, Department of Medicine, University of Verona
- Gianluigi Zaza
- Renal Unit, Department of Medicine, University of Verona
- Francesca Lugani
- Division of Nephrology, Dialysis, Transplantation, IRCCS Giannina Gaslini
- GianMarco Ghiggeri
- Division of Nephrology, Dialysis, Transplantation, IRCCS Giannina Gaslini
- Isabella Pisani
- Department of Medicine and Surgery, University of Parma
- Landino Allegri
- Department of Medicine and Surgery, University of Parma
- Ben Sprangers
- Department of Microbiology and Immunology, Laboratory of Molecular Immunology, Rega Institute, KU
- Jin-Ho Park
- Department of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital
- BeLong Cho
- Department of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital
- Yon Su Kim
- Biomedical Sciences, Seoul National University College of Medicine
- Dong Ki Kim
- Kidney Research Institute, Seoul National University College of Medicine
- Hitoshi Suzuki
- Department of Nephrology, Juntendo University Faculty of Medicine
- Antonio Amoroso
- Department of Medical Sciences, University of Torino and Immunogenetics and Transplant Biology Service, University Hospital “Città della Salute e della Scienza di Torino”
- Daniel C. Cattran
- Department of Nephrology, University of Toronto, Toronto General Hospital
- Fernando C. Fervenza
- Division of Nephrology and Hypertension, Mayo Clinic
- Antonello Pani
- Department of Nephrology and Dialysis, G. Brotzu Hospital
- Patrick Hamilton
- Manchester Institute of Nephrology and Transplantation, Manchester University Hospitals NHS Trust
- Shelly Harris
- Manchester Institute of Nephrology and Transplantation, Manchester University Hospitals NHS Trust
- Sanjana Gupta
- Department of Nephrology, Division of Medicine, University College London
- Chris Cheshire
- Department of Nephrology, Division of Medicine, University College London
- Stephanie Dufek
- Department of Nephrology, Division of Medicine, University College London
- Naomi Issler
- Department of Nephrology, Division of Medicine, University College London
- Ruth J. Pepper
- Department of Nephrology, Division of Medicine, University College London
- John Connolly
- Department of Nephrology, Division of Medicine, University College London
- Stephen Powis
- Department of Nephrology, Division of Medicine, University College London
- Detlef Bockenhauer
- Department of Nephrology, Division of Medicine, University College London
- Horia C. Stanescu
- Department of Nephrology, Division of Medicine, University College London
- Neil Ashman
- Renal Unit, Royal London Hospital, Barts Health, Whitechapel
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Eimear E. Kenny
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Matthias Wuttke
- Institute of Genetic Epidemiology, Dep. of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center – University of Freiburg
- Kai-Uwe Eckardt
- Department of Nephrology and Medical Intensive Care, Charité – Universitätsmedizin Berlin
- Anna Köttgen
- Institute of Genetic Epidemiology, Dep. of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center – University of Freiburg
- Julia M. Hofstra
- Department of Nephrology, Radboud University Medical Center
- Marieke J. H. Coenen
- Department of Human Genetics, Radboud University Medical Centre, Radboud Institute for Health Sciences
- Lambertus A. Kiemeney
- Department of Epidemiology, Biostatistics & HTA, Radboud University Medical Center
- Shreeram Akilesh
- Department of Anatomic Pathology, University of Washington
- Matthias Kretzler
- Division of Nephrology, Department of Medicine, University of Michigan
- Lawrence H. Beck
- Department of Medicine, Renal Section, Boston University School of Medicine and Boston Medical Center
- Benedicte Stengel
- Institut National de la Santé et de la Recherche Médicale, Centre for Research in Epidemiology and Population Health
- Hanna Debiec
- Sorbonne Université, Pierre and Marie Curie University Paris 06
- Pierre Ronco
- Sorbonne Université, Pierre and Marie Curie University Paris 06
- Jack F. M. Wetzels
- Department of Nephrology, Radboud University Medical Center
- Magdalena Zoledziewska
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche
- Francesco Cucca
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche
- Iuliana Ionita-Laza
- Department of Biostatistics, Mailman School of Public Health, Columbia University
- Hajeong Lee
- Kidney Research Institute, Seoul National University College of Medicine
- Elion Hoxha
- III Department of Medicine, University Medical Center Hamburg-Eppendorf
- Rolf A. K. Stahl
- III Department of Medicine, University Medical Center Hamburg-Eppendorf
- Paul Brenchley
- Faculty of Biology, Medicine, Health, University of Manchester
- Francesco Scolari
- Second Division of Nephrology, ASST-Spedali Civili di Brescia Presidio di Montichiari
- Ming-hui Zhao
- Renal Division, Department of Medicine, Peking University First Hospital
- Ali G. Gharavi
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- Robert Kleta
- Department of Nephrology, Division of Medicine, University College London
- Nan Chen
- Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Krzysztof Kiryluk
- Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons
- DOI
- https://doi.org/10.1038/s41467-020-15383-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.
