Proliferative polyploid cells give rise to tumors via ploidy reduction

Tomonori Matsumoto; Leslie Wakefield; Alexander Peters; Myron Peto; Paul Spellman; Markus Grompe

doi:10.1038/s41467-021-20916-y

Nature Communications (Jan 2021)

Proliferative polyploid cells give rise to tumors via ploidy reduction

Tomonori Matsumoto,
Leslie Wakefield,
Alexander Peters,
Myron Peto,
Paul Spellman,
Markus Grompe

Affiliations

Tomonori Matsumoto: Department of Pediatrics, Oregon Health and Science University
Leslie Wakefield: Department of Pediatrics, Oregon Health and Science University
Alexander Peters: Department of Pediatrics, Oregon Health and Science University
Myron Peto: Department of Molecular and Medical Genetics, Oregon Health and Science University
Paul Spellman: Department of Molecular and Medical Genetics, Oregon Health and Science University
Markus Grompe: Department of Pediatrics, Oregon Health and Science University

DOI: https://doi.org/10.1038/s41467-021-20916-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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The involvement of polyploid hepatocytes in liver tumorigenesis is unclear. Here the authors use in vivo lineage tracing and show that polyploid hepatocytes initiate tumour formation through frequent ploidy reduction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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