Nature Communications (Jul 2019)

Mutation bias and GC content shape antimutator invasions

  • Alejandro Couce,
  • Olivier Tenaillon

DOI
https://doi.org/10.1038/s41467-019-11217-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics.