Pediatric asthma comorbidities: Global impact and unmet needs

Elham Hossny, MD, PhD; Yuichi Adachi, MD, PhD; Eleni Anastasiou, MD; Héctor Badellino, MD, PhD; Adnan Custovic, PhD; Rasha El-Owaidy, MD, PhD; Zeinab A. El-Sayed, MD, PhD; Ivana Filipovic, MD, PhD; R. Maximiliano Gomez, MD, PhD; Ömer Kalayci, MD; Peter Le Souëf, FRACP, MD; Michael Miligkos, MD, PhD; Mário Morais-Almeida, MD, PhD; Antonio Nieto, MD, PhD; Wanda Phipatanakul, MD; Ghada Shousha, MD, PhD; Alvaro Teijeiro, MD, PhD; Jiu-Yao Wang, MD, DPhil; Gary W.K. Wong, MD, FRCPC, FHKAM; Paraskevi Xepapadaki, MD, PhD; Su Boon Yong, MD, PhD; Nikolaos G. Papadopoulos, MD, PhD

World Allergy Organization Journal (May 2024)

Pediatric asthma comorbidities: Global impact and unmet needs

Elham Hossny, MD, PhD,
Yuichi Adachi, MD, PhD,
Eleni Anastasiou, MD,
Héctor Badellino, MD, PhD,
Adnan Custovic, PhD,
Rasha El-Owaidy, MD, PhD,
Zeinab A. El-Sayed, MD, PhD,
Ivana Filipovic, MD, PhD,
R. Maximiliano Gomez, MD, PhD,
Ömer Kalayci, MD,
Peter Le Souëf, FRACP, MD,
Michael Miligkos, MD, PhD,
Mário Morais-Almeida, MD, PhD,
Antonio Nieto, MD, PhD,
Wanda Phipatanakul, MD,
Ghada Shousha, MD, PhD,
Alvaro Teijeiro, MD, PhD,
Jiu-Yao Wang, MD, DPhil,
Gary W.K. Wong, MD, FRCPC, FHKAM,
Paraskevi Xepapadaki, MD, PhD,
Su Boon Yong, MD, PhD,
Nikolaos G. Papadopoulos, MD, PhD

Affiliations

Elham Hossny, MD, PhD: Pediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt; Corresponding author. Pediatric allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo 11566, Egypt
Yuichi Adachi, MD, PhD: Pediatric Allergy Center, Toyama Red Cross Hospital, Japan
Eleni Anastasiou, MD: Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Héctor Badellino, MD, PhD: Faculty of Psychology, UCES University, San Francisco, Argentina
Adnan Custovic, PhD: National Heart and Lung Institute, Imperial College London, London, UK
Rasha El-Owaidy, MD, PhD: Pediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
Zeinab A. El-Sayed, MD, PhD: Pediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
Ivana Filipovic, MD, PhD: University Hospital dr Dragisa Misovic, Belgrade, Serbia
R. Maximiliano Gomez, MD, PhD: Faculty of Health Sciences, Catholic University of Salta, Argentina
Ömer Kalayci, MD: Hacettepe University School of Medicine, Ankara, Turkey
Peter Le Souëf, FRACP, MD: School of Medicine, University of Western Australia, Perth, WA, Australia
Michael Miligkos, MD, PhD: Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Mário Morais-Almeida, MD, PhD: Allergy Center Hospital CUF-Descobertas, Lisbon, Portugal
Antonio Nieto, MD, PhD: Pediatric Pulmonology and Allergy Unit, Hospital Universitari i Politècnic La Fe, Health Research Institute La Fe, Valencia, Spain
Wanda Phipatanakul, MD: Division of Allergy and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
Ghada Shousha, MD, PhD: Pediatric Allergy, Immunology, and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
Alvaro Teijeiro, MD, PhD: Respiratory Department, Pediatric Hospital, Córdoba, Argentina
Jiu-Yao Wang, MD, DPhil: Allergy, Immunology and Microbiome Research Center, China Medical University Children's Hospital, Taichung, Taiwan
Gary W.K. Wong, MD, FRCPC, FHKAM: Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
Paraskevi Xepapadaki, MD, PhD: Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Su Boon Yong, MD, PhD: Department of Allergy and Immunology, China Medical University Children's Hospital, Taichung, Taiwan
Nikolaos G. Papadopoulos, MD, PhD: Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK

Journal volume & issue: Vol. 17, no. 5
p. 100909

Abstract

Read online

Real-world data on the range and impact of comorbid health conditions that affect pediatric asthma are scant, especially from developing countries. Lack of data hinders effective diagnosis, treatment, and overall management of these complex cases. We, hereby, describe the common pediatric asthma comorbid conditions in terms of evidence for association, potential mechanisms of impact on asthma control, and treatment benefit. Obesity, upper airway allergies, dysfunctional breathing, multiple sensitizations, depressive disorders, food allergy, and gastro-esophageal reflux are common associations with difficult-to-treat asthma. On the other hand, asthma symptoms and/or management may negatively impact the well-being of children through drug adverse effects, worsening of anaphylaxis symptoms, and disturbing mental health.Awareness of these ailments may be crucial for designing the optimum care for each asthmatic child individually and may ultimately improve the quality of life of patients and their families. A multidisciplinary team of physicians is required to identify and manage such comorbidities aiming to mitigate the over-use of asthma pharmacotherapy. Asthma research should target relevant real-world difficulties encountered at clinical practice and focus on interventions that would mitigate the impact of such comorbidities. Finally, policymakers and global healthcare organizations are urged to recognize pediatric asthma control as a healthcare priority and allocate resources for research and clinical interventions. In other words, global asthma control needs support by compassionate scientific partnership.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

About the journal

Abstract

Keywords