mBio
(Jun 2021)
Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus
Zhonghua Liu,
Shriya Raj,
Norman van Rhijn,
Marcin Fraczek,
Jean-Philippe Michel,
Odile Sismeiro,
Rachel Legendre,
Hugo Varet,
Thierry Fontaine,
Michael Bromley,
Jean-Paul Latgé
Affiliations
Zhonghua Liu
Unité des Aspergillus, Institut Pasteur, Paris, France
Shriya Raj
Unité des Aspergillus, Institut Pasteur, Paris, France
Norman van Rhijn
Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom
Marcin Fraczek
Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom
Jean-Philippe Michel
Institut Galien Paris Sud, UMR CNRS 8612, Châtenay-Malabry, France
Odile Sismeiro
Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France
Rachel Legendre
Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France
Hugo Varet
ORCiD Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France
Thierry Fontaine
Unité des Aspergillus, Institut Pasteur, Paris, France
Michael Bromley
Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom
Jean-Paul Latgé
Unité des Aspergillus, Institut Pasteur, Paris, France
DOI
https://doi.org/10.1128/mBio.00863-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
The compound Congo red (CR) has been historically used for coloring treatment and histological examination as well to inhibit the growth of yeast and filamentous fungi. It has been thought that CR binds to β-1,3-glucans in the fungal cell wall, disrupting the organization of the cell wall structure.
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