INNOVATIVE TECHNOLOGIES IN THE IMMUNOLOGICAL DIAGNOSIS OF TUBERCULOSIS IN CONTACTS OF THE CENTERS OF TUBERCULOSIS INFECTION

Abstract

Purpose: comparative estimation of the efficacy of Mantoux test with 2 TE PPD-L, DiaskintestR, and QuantiFERONRTBGoldfor identification of active and latent tuberculosis infection at contact persons.Materials and Мethods: the study included 220 people from tuberculosis infection foci. All contact persons underwent the Mantoux test with 2 TE PPD-L and the DiaskintestR. The in vitro QuantiFERONRTBGold test was done before the intracutaneous probes. The statistical manipulation of the obtained data was performed using the Statistica 6.0 package under Windows XP.Results: the Mantoux test with 2 TE PPD-L was reliably not distinguished for persons with active tuberculosis, residual posttuberculosis changes, and latent tuberculosis infections. DiaskintestR and QuantiFERONRTBGold possessed statistically significant differences depending on the investigated group.Summary: the Mantoux test with 2 TE PPD-L has low sensitivity and specificity, and not effective enough to detect active and latent tuberculosis infection. The usage of DiaskintestR and QuantiFERONRTBGold allows to detect and identify tuberculosis infection both active and latent.

Keywords

• tuberculosis, mantoux test 2 te ppd-l, diaskintes*, quantiferon*tbgold