Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes

Qin Ma; Hengameh Shams; Alessandro Didonna; Sergio E. Baranzini; Bruce A. C. Cree; Stephen L. Hauser; Roland G. Henry; Jorge R. Oksenberg

doi:10.1038/s42003-023-04713-5

Communications Biology (Mar 2023)

Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes

Qin Ma,
Hengameh Shams,
Alessandro Didonna,
Sergio E. Baranzini,
Bruce A. C. Cree,
Stephen L. Hauser,
Roland G. Henry,
Jorge R. Oksenberg

Affiliations

Qin Ma: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco
Hengameh Shams: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco
Alessandro Didonna: Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University
Sergio E. Baranzini: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco
Bruce A. C. Cree: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco
Stephen L. Hauser: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco
Roland G. Henry: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco
Jorge R. Oksenberg: Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco

DOI: https://doi.org/10.1038/s42003-023-04713-5
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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The combined analysis of single cell and bulk epigenetic datasets and multiple sclerosis GWAS reveals the enrichment of genetic susceptibility signals in B cells and monocyte-microglia cell types.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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