In-vivo anti-hyperglycemic effect of herbal extracts Tribulus terrestris (L) and Curcuma amada (R) on streptozotocin-induced diabetic rats and its associated histopathological studies
Kumaravel Kaliaperumal,
Bilal Ahmad Bhat,
Kumaran Subramanian,
Thiruchelvi Ramakrishnan,
Elanchezhiyan Chakravarthy,
Lamya Ahmed Al-Keridis,
Irfan Ahmad,
Nadiyah M. Alabdallah,
Mohd Saeed,
Rohini Karunakaran
Affiliations
Kumaravel Kaliaperumal
Unit of Biomaterials Research, Department of Orthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India
Bilal Ahmad Bhat
Unit of Ethnopharmacology, Department of Zoology, Annamalai University, Chidambaram, Tamil Nadu, India
Kumaran Subramanian
P.G.Research Department of Microbiology, Sri Sankara Arts and Science College (Autonomous), Enathur, Kanchipuram, Tamil Nadu, India
Thiruchelvi Ramakrishnan
Aman Aqua Bio Chemical Free Plant Activator Manufacturer, Rameshwaram, Tamil Nadu, India
Elanchezhiyan Chakravarthy
Unit of Ethnopharmacology, Department of Zoology, Annamalai University, Chidambaram, Tamil Nadu, India
Lamya Ahmed Al-Keridis
Department of Biology, Faculty of Science, Princess Nourah Bint Abdulrahman University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia
Irfan Ahmad
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
Nadiyah M. Alabdallah
Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O.Box 1982, 31441, Dammam, Saudi Arabia; Basic and Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University, P.O.Box 1982, 31441, Dammam, Saudi Arabia
Mohd Saeed
Department of Biology, College of Sciences, University of Hail, Hail, Saudi Arabia
Rohini Karunakaran
Department of Computational Biology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India; Unit of Biochemistry, Faculty of Medicine, AIMST University, Semeling, Bedong, Malaysia; Corresponding author. Unit of Biochemistry, Faculty of Medicine, AIMST University, Semeling, Bedong, Malaysia
Dia/betes is a serious health concern in many countries with high blood glucose, obesity, and multiple organ failures in late stages. Treating diabetes with effective drugs is still a challenging issue since most of the available diabetic drugs are not effective in combating diabetes, especially in secondary disease complications like obesity, retinopathy, and nephropathy associated with diabetes. Hence search for effective antidiabetic medication, especially from natural sources is mandatory with no adverse side effects. In the present study, a combined herbal aqueous extract of Tribulus terrestris and Curcuma amada was administered to diabetic-induced rats for 37 days. During experimentation, the mean blood glucose level was estimated and at the end of the experiment on the 37th day, the animal was sacrificed and observed for weight gain, plasma insulin, glycogen, glycated hemoglobin, urea, and creatinine level. The results revealed that TT and CA extract-treated diabetic groups significantly lowered the mean blood glucose level followed by increased glycogen and insulin level. Urea, creatinine, and HbA1c levels were considerably reduced in TT and CA-treated diabetic animals as compared to that of antidiabetic drug Glibenclamide-treated groups. TT and CA-treated diabetic animals showed considerable net body weight gain at the end of the experimental day. A concluding remark of the study shows that TT and CA herbal extract is effective against diabetes and it can be considered as an antidiabetic agent in ayurvedic medicine practice.
