Involvement of the GABAergic system in PTSD and its therapeutic significance

Junhui Huang; Fei Xu; Liping Yang; Lina Tuolihong; Xiaoyu Wang; Zibo Du; Yiqi Zhang; Xuanlin Yin; Yingjun Li; Kangrong Lu; Wanshan Wang

doi:10.3389/fnmol.2023.1052288

Frontiers in Molecular Neuroscience (Feb 2023)

Involvement of the GABAergic system in PTSD and its therapeutic significance

Junhui Huang,
Fei Xu,
Liping Yang,
Lina Tuolihong,
Xiaoyu Wang,
Zibo Du,
Yiqi Zhang,
Xuanlin Yin,
Yingjun Li,
Kangrong Lu,
Wanshan Wang

Affiliations

Junhui Huang: Southern Medical University, Guangzhou, China
Fei Xu: Southern Medical University, Guangzhou, China
Liping Yang: Department of Applied Psychology of School of Public Health, Southern Medical University, Guangzhou, China
Lina Tuolihong: Department of Basic Medical of Basic Medical College, Southern Medical University, Guangzhou, China
Xiaoyu Wang: Eight-Year Master’s and Doctoral Program in Clinical Medicine of the First Clinical Medical College, Southern Medical University, Guangzhou, China
Zibo Du: Eight-Year Master’s and Doctoral Program in Clinical Medicine of the First Clinical Medical College, Southern Medical University, Guangzhou, China
Yiqi Zhang: Eight-Year Master’s and Doctoral Program in Clinical Medicine of the First Clinical Medical College, Southern Medical University, Guangzhou, China
Xuanlin Yin: Department of Basic Medical of Basic Medical College, Southern Medical University, Guangzhou, China
Yingjun Li: Department of Medical Laboratory Science, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
Kangrong Lu: Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, China
Wanshan Wang: Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fnmol.2023.1052288
Journal volume & issue: Vol. 16

Abstract

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The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear conditioning. The GABAergic system is involved in the pathophysiological process of PTSD, with several studies demonstrating that the function of the GABAergic system decreases in PTSD patients. This paper reviews the preclinical and clinical studies, neuroimaging techniques, and pharmacological studies of the GABAergic system in PTSD and summarizes the role of the GABAergic system in PTSD. Understanding the role of the GABAergic system in PTSD and searching for new drug targets will be helpful in the treatment of PTSD.

Published in Frontiers in Molecular Neuroscience

ISSN: 1662-5099 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/molecular-neuroscience

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Abstract

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