Вопросы современной педиатрии (Jan 2011)

The role of pneumococcal infection in development of exacerbations in children with bronchial asthma and obstructive bronchitis

  • N.V. Kukhtinova,
  • S.M. Gavalov,
  • S.A. Krotov,
  • V.A. Krotova

Journal volume & issue
Vol. 10, no. 2
pp. 22 – 27

Abstract

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Pneumococcal infection remains the key cause of severe diseases of lower airways and deaths in children. The objective: to study the role of pneumococcal infection in pathogenesis of exacerbations of recurrent obstructive pulmonary diseases. Methods: etiological structure of lower airways infections was evaluated in 125 patients 1–15 years old with bronchial asthma or recurrent bronchitis. Results: etiologic role of Streptococcus pneumoniae in development of low airways infections was detected in 48% of patients with atopic asthma, 85% — with asthma without atopy, 97% — with recurrent bronchitis. Repeated microbiological examination confirmed chronic carriage of S. рneumoniae in nasopharinx in 31% of patients. Conclusion: early active prophylaxis with vaccine against pneumococcal infection including conjugated vaccines is able to prevent further progression of a disease.Key words: children, bronchial asthma, obstructive bronchitis, exacerbation, pneumococcal infection.