The effect of hydrogen sulfide on electrical and contractile activity of smooth muscle cells in guinea pig ureter

Abstract

The effect of donor hydrogen sulfide NaHS for electrical and contractile activity of smooth muscle cells in guinea pig ureter is present in biologically active compounds histamine and phenylephrine, an activator of adenylate cyclase forskolin, blockers of Na+/H+-exchanger, Na+,K+,2Cl–-cotransporter and potassium conductance of the membrane were studied by the method of the double sucrose gap junction. It is shown that the activating effect of NaHS largely determined by the interference of Na+-mediated ion transporters in the cAMP-dependent inhibition of the potassium conductance of the membrane of smooth muscle cells.

Keywords

• гладкомышечные клетки
• сероводород
• биологически активные вещества
• калиевая проводимость мембраны