Graphene Oxide Thin Films with Drug Delivery Function
Alexandra M. L. Oliveira,
Mónica Machado,
Gabriela A. Silva,
Diogo B. Bitoque,
Joana Tavares Ferreira,
Luís Abegão Pinto,
Quirina Ferreira
Affiliations
Alexandra M. L. Oliveira
Instituto de Telecomunicações, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal
Mónica Machado
Instituto de Telecomunicações, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal
Gabriela A. Silva
iNOVA4Health, CEDOC Chronic Diseases Research Centre, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal
Diogo B. Bitoque
iNOVA4Health, CEDOC Chronic Diseases Research Centre, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal
Joana Tavares Ferreira
Ophthalmology Department, Centro Hospitalar Universitário de Lisboa Norte, 1649-035 Lisbon, Portugal
Luís Abegão Pinto
Ophthalmology Department, Centro Hospitalar Universitário de Lisboa Norte, 1649-035 Lisbon, Portugal
Quirina Ferreira
Instituto de Telecomunicações, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal
Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.
