Spotlight on borderline-IGHV mutational status in chronic lymphocytic leukemia

Souraya Rammal; Warde Semaan; Natalia Aprahamian; Romy Moussallem; Alain Chebly; Alain Chebly

doi:10.3389/fonc.2024.1430225

Frontiers in Oncology (Jun 2024)

Spotlight on borderline-IGHV mutational status in chronic lymphocytic leukemia

Souraya Rammal,
Warde Semaan,
Natalia Aprahamian,
Romy Moussallem,
Alain Chebly,
Alain Chebly

Affiliations

Souraya Rammal: Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Warde Semaan: Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Natalia Aprahamian: Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Romy Moussallem: Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Alain Chebly: Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
Alain Chebly: Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon

DOI: https://doi.org/10.3389/fonc.2024.1430225
Journal volume & issue: Vol. 14

Abstract

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Mutated or unmutated immunoglobulin heavy chain (IGHV) gene is an important prognostic factor in chronic lymphocytic leukemia (CLL). However, a small fraction of patients with CLL are classified as borderline (BL)-IGHV. Few data are available on this subgroup of CLL. In this paper, we retrospectively report and analyze data from 21 patients with BL-IGHV CLL, showing the heterogeneity of this subgroup of CLL and paving the way for more research focusing on this entity to optimize the management and treatment of patients with Borderline-IGHV CLL.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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