The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

Geng Liu; Wojciech Barczak; Lian Ni Lee; Amit Shrestha; Nicholas M. Provine; Gulsah Albayrak; Hong Zhu; Claire Hutchings; Paul Klenerman; Nicholas B. La Thangue

doi:10.1038/s42003-023-04485-y

Communications Biology (Jan 2023)

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

Geng Liu,
Wojciech Barczak,
Lian Ni Lee,
Amit Shrestha,
Nicholas M. Provine,
Gulsah Albayrak,
Hong Zhu,
Claire Hutchings,
Paul Klenerman,
Nicholas B. La Thangue

Affiliations

Geng Liu: Laboratory of Cancer Biology, Department of Oncology, University of Oxford
Wojciech Barczak: Laboratory of Cancer Biology, Department of Oncology, University of Oxford
Lian Ni Lee: Peter Medawar Building for Pathogen Research, University of Oxford
Amit Shrestha: Laboratory of Cancer Biology, Department of Oncology, University of Oxford
Nicholas M. Provine: Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
Gulsah Albayrak: Laboratory of Cancer Biology, Department of Oncology, University of Oxford
Hong Zhu: Laboratory of Cancer Biology, Department of Oncology, University of Oxford
Claire Hutchings: Peter Medawar Building for Pathogen Research, University of Oxford
Paul Klenerman: Peter Medawar Building for Pathogen Research, University of Oxford
Nicholas B. La Thangue: Laboratory of Cancer Biology, Department of Oncology, University of Oxford

DOI: https://doi.org/10.1038/s42003-023-04485-y
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 14

Abstract

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The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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